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Chemical genetics in <i>C. elegans</i> identifies anticancer mycotoxins chaetocin and chetomin as potent inducers of a nuclear metal homeostasis response

2024-02-20

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<h4>ABSTRACT</h4> C. elegans numr-1/2 ( nu clear-localized m etal-responsive) is an identical gene pair encoding a nuclear protein previously shown to be activated by cadmium and disruption of the integrator RNA metabolism complex. We took a chemical genetic approach to further characterize regulation of this novel metal response by screening 41,716 compounds and extracts for numr-1p::GFP activation. The most...

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Literature Corpus work
5e50ac7b-46c5-522a-b6f9-40c5fed909ac
DOI
10.1101/2024.02.15.579914
Open publication

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Chemical genetics in <i>C. elegans</i> identifies anticancer mycotoxins chaetocin and chetomin as potent inducers of a nuclear metal homeostasis responseDOI 10.1101/2024.02.15.579914
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