Cadmium-induced POLN mutations promote m6A-dependent circ_FANCA degradation via endoribonucleolytic cleavage, triggering TCA cycle activation and oncogenic transformation.

Abstract excerpt

Cadmium (Cd) is a heavy metal with well-documented carcinogenic properties. While both genetic and epigenetic modifications have been demonstrated to contribute to Cd-induced carcinogenesis through the dysregulation of oncogenic signaling pathways,the mechanistic crosstalk between them is not fully elucidated. Here, we combined a Cd-induced cellular malignant transformation model with integrated genomic and...

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