Article
Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans.
PloS one - 5 Mar 2010
Schwartz Marc S, Benci Joseph L, Selote Devarshi S, Sharma Anuj K, Chen Andy G Y, Dang Hope, Fares Hanna, Vatamaniuk Olena K
Abstract excerpt
BACKGROUND: Developing methods for protecting organisms in metal-polluted environments is contingent upon our understanding of cellular detoxification mechanisms. In this regard, half-molecule ATP-binding cassette (ABC) transporters of the HMT-1 subfamily are required for cadmium (Cd) detoxification. HMTs have conserved structural architecture that distinguishes them from other ABC transporters and allows the...
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