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Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in <i>Caenorhabditis elegans</i>

2019-03-11

Abstract excerpt

Zinc is essential for cellular functions as it is a catalytic and structural component of many proteins. In contrast, cadmium is not required in biological systems and is toxic. Zinc and cadmium levels are closely monitored and regulated as their excess causes cell stress. To maintain homeostasis, organisms induce metal detoxification gene programs through stress responsive transcriptional regulatory complexes. In...

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Literature Corpus work
460dc080-fc83-5240-8530-9c04efe94acb
DOI
10.1101/565739
Open publication

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Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in <i>Caenorhabditis elegans</i>DOI 10.1101/565739
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