Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

10 May 2024

Abstract excerpt

High-altitude hypoxia acclimatization requires whole-body physiological regulation in highland immigrants, but the underlying genetic mechanism has not been clarified. Here we use sheep as an animal model for low-to-high altitude translocation. We generate multi-omics data including whole-genome sequences, time-resolved bulk RNA-Seq, ATAC-Seq and single-cell RNA-Seq from multiple tissues as well as phenotypic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Cancer, Hypoxia, and Metabolism
Share to High Altitude and Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38730227
DOI: 10.1038/s41467-024-48261-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissuesPMID 38730227Read ↗

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissuesSemantic proximity Read ↗

Transcriptomic analysis provides insight into high-altitude acclimation in domestic goats.Semantic proximity Read ↗

Genomic Insights into Tibetan Sheep Adaptation to Different Altitude Environments.Semantic proximity Read ↗

Seq-ing Higher Ground: Functional Investigation of Adaptive Variation Associated With High-Altitude AdaptationSemantic proximity Read ↗

Physiological Genomics of Adaptation to High-Altitude Hypoxia.Semantic proximity Read ↗

Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation.Semantic proximity Read ↗

The transcriptomic landscape of yaks reveals molecular pathways for high altitude adaptationSemantic proximity Read ↗

Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep.Semantic proximity Read ↗

Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation.Semantic proximity Read ↗

The human blood transcriptome exhibits time-of-day-dependent response to hypoxia: Lessons from the highest city in the worldSemantic proximity Read ↗

DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseasesSemantic proximity Read ↗

Comparative Analysis of Long Non-Coding RNA and mRNA Expression Provides Insights Into Adaptation to Hypoxia in Tibetan SheepSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.