Article

Long-read Spatial Transcriptomic Profiling of Patient-derived ccRCC Tumoroids Reveals Heterogeneity in Isoform and Gene Expression

2024-10-18

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of kidney cancer characterized by its diverse tumor composition featuring various subclonal populations that hinder effective treatment responses. Tumoroids present an avenue for modelling this diversity and replicating the intricate tumor heterogeneity. Spatial transcriptomics preserves the spatial context of gene expression enabling us to study d...

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Literature Corpus work: 5e336691-b3be-5549-a40f-89fab8b3cefb
DOI: 10.1101/2024.10.16.618643

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