Article

Spatial transcriptomics reveals site-specific cellular and metabolic heterogeneity in bladder carcinoma in situ

2026-08-31

Abstract excerpt

Bladder carcinoma in situ (CIS) is a multifocal, non-muscle-invasive disease with a high risk of progression to muscle-invasive cancer. Current management strategies are often guided by genomic profiling of single tumor samples, which incompletely capture tumor heterogeneity and may contribute to treatment failure. In particular, the multifocal nature of CIS raises uncertainty regarding the uniformity of genomic,...

Identifiers and source

Literature Corpus work: dda8bd0d-9e94-574a-9e2e-8f3e2980f947
DOI: 10.64898/2026.08.27.741603

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Spatial transcriptomics reveals site-specific cellular and metabolic heterogeneity in bladder carcinoma in situDOI 10.64898/2026.08.27.741603Read

Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosisSemantic proximity Read

Integrated spatial transcriptome and metabolism study reveals metabolic heterogeneity in human bladder cancerSemantic proximity Read

Single-Cell Proteomic Analysis Dissects the Complexity of Tumor Microenvironment in Muscle Invasive Bladder CancerSemantic proximity Read

Single-cell RNA sequencing and spatial transcriptome analysis in bladder cancer: Current status and future perspectivesSemantic proximity Read

Spatial omics for profiling the dynamic tumor microenvironmentSemantic proximity Read

Digital spatial profiling of the microenvironment of muscle invasive bladder cancerSemantic proximity Read

A spatially resolved whole-layers landscape of bladder cancer deciphers dynamic invasive progressionSemantic proximity Read

Distinct clonal dynamics and interactions within the microenvironment near tumor stroma interfaces in rare histologic variants of bladder cancerSemantic proximity Read

Epigenomic analysis of high-grade T1 bladder cancer reveals subtypes with clinical implications that display extensive intra-tumor heterogeneity with spatial features.Semantic proximity Read

Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinomaSemantic proximity Read

Benchmarking of spatial transcriptomics platforms across six cancer typesSemantic proximity Read