Article
Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors.
Oncotarget - 20 Oct 2015
Baldelli Elisa, Bellezza Guido, Haura Eric B, Crinó Lucio, Cress W Douglas, Deng Jianghong, Ludovini Vienna, Sidoni Angelo, Schabath Matthew B, Puma Francesco, Vannucci Jacopo, Siggillino Annamaria, Liotta Lance A, Petricoin Emanuel F, Pierobon Mariaelena
Abstract excerpt
Little is known about the complex signaling architecture of KRAS and the interconnected RAS-driven protein-protein interactions, especially as it occurs in human clinical specimens. This study explored the activated and interconnected signaling network of KRAS mutant lung adenocarcinomas (AD) to identify novel therapeutic targets.Thirty-four KRAS mutant (MT) and twenty-four KRAS wild-type (WT) frozen biospecimens...
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