Article

A mechanically regulated liquid-liquid phase separation of the transcriptional regulator Tono instructs muscle development

2023-08-28

Abstract excerpt

Muscle morphogenesis is a multi-step program, starting with myoblast fusion, followed by myotube-tendon attachment and sarcomere assembly, with subsequent sarcomere maturation, mitochondrial amplification and specialisation. The correct chronological order of these steps requires precise control of the transcriptional regulators and their effectors. How this regulation is achieved during muscle development is not...

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Identifiers and source

Literature Corpus work: 17cc38b9-46b2-5c3d-9aeb-8c9aa9039627
DOI: 10.1101/2023.08.27.555003

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