Article
Unifying the epidemiological and evolutionary dynamics of pathogens.
Science (New York, N.Y.) - 16 Jan 2004
Grenfell Bryan T, Pybus Oliver G, Gog Julia R, Wood James L N, Daly Janet M, Mumford Jenny A, Holmes Edward C
Abstract excerpt
A key priority for infectious disease research is to clarify how pathogen genetic variation, modulated by host immunity, transmission bottlenecks, and epidemic dynamics, determines the wide variety of pathogen phylogenies observed at scales that range from individual host to population. We call the melding of immunodynamics, epidemiology, and evolutionary biology required to achieve this synthesis pathogen...
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