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Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

23 Apr 2021

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses subgenomic RNA (sgRNA) to produce viral proteins for replication and immune evasion. We apply long-read RNA and cDNA sequencing to in vitro human and primate infection models to study transcriptional dynamics. Transcription-regulating sequence (TRS)-dependent sgRNA upregulates earlier in infection than TRS-independent sgRNA. An abundant class of...

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PMID: 33961822
DOI: 10.1016/j.celrep.2021.109108

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