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SARS-CoV-2: from its discovery to genome structure, transcription, and replication

19 Jul 2021

Abstract excerpt

Abstract SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant genetic shift from different isolates. After entering the susceptible cells expressing both ACE2 and TMPRSS2, the SARS-CoV-2 genome directly functions as an...

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PMID: 34281608
DOI: 10.1186/s13578-021-00643-z

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