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Article

Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2

30 Nov 2020

Abstract excerpt

BACKGROUND: SARS-CoV-2, a positive-sense RNA virus in the family Coronaviridae, has caused a worldwide pandemic of coronavirus disease 2019 or COVID-19. Coronaviruses generate a tiered series of subgenomic RNAs (sgRNAs) through a process involving homology between transcriptional regulatory sequences (TRS) located after the leader sequence in the 5' UTR (the TRS-L) and TRS located near the start of ORFs encoding...

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PMID: 33256807
DOI: 10.1186/s13073-020-00802-w

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