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Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities

19 Jun 2018

Abstract excerpt

The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk, yet our understanding of normal mammary cell composition is incomplete. Here, we build a multimodal resource for the adult gland through comprehensive profiling of primary cell epigenomes,...

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PMID: 29921600
DOI: 10.1083/jcb.201804042

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