Article
Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells.
Aging - 9 Oct 2017
Miyano Masaru, Sayaman Rosalyn W, Stoiber Marcus H, Lin Chun-Han, Stampfer Martha R, Brown James B, LaBarge Mark A
Abstract excerpt
Luminal epithelial cells in the breast gradually alter gene and protein expression with age, appearing to lose lineage-specificity by acquiring myoepithelial-like characteristics. We hypothesize that the luminal lineage is particularly sensitive to microenvironment changes, and age-related microenvironment changes cause altered luminal cell phenotypes. To evaluate the effects of different microenvironments on the...
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