Article
Biochemical Patterns of Antibody Polyreactivity Revealed Through a Bioinformatics-Based Analysis of CDR Loops
2020-07-30
Abstract excerpt
Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high affinity, yet some maintain an additional basal level of low affinity, broad reactivity to diverse epitopes, a phenomenon termed “polyreactivity”. While polyreactivity has been observed in antibodies isolated from various immunological niches, the bi...
Topics
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- Antibodies, Neutralizing
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Toxin Mechanisms and Immunotoxins
- vaccines and immunoinformatics approaches
- Viral Infectious Diseases and Gene Expression in Insects
Identifiers and source
- Literature Corpus work
- 2f8a5f0e-c7bc-5442-9c41-77d29f30d744
- DOI
- 10.1101/2020.07.30.229013