Article

Stability of c-Myc protein differentiates Ras oncogene addiction and MAPK pathway dependency in Ras-mutant multiple myeloma

2026-08-20

Abstract excerpt

<title>Abstract</title> <p>Multiple myeloma (MM) is a plasma cell malignancy that frequently harbors activating mutations in NRAS and KRAS oncogenes. Previous clinical trials targeting the Ras/MAPK oncogenic pathway with MEK inhibitors (MEKi) were met with limited efficacy, and newer generation of Ras inhibitors (RASi) have not been specifically evaluated in MM patients. To investigate the vulnerabilities of Ras-...

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Literature Corpus work: 5db07550-c1a9-567a-b145-af8d4dffed80
DOI: 10.21203/rs.3.rs-10581102/v1

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