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Article

Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma.

Blood advances - 12 Nov 2019

Lin Yu-Hsiu T, Way Gregory P, Barwick Benjamin G, Mariano Margarette C, Marcoulis Makeba, Ferguson Ian D, Driessen Christoph, Boise Lawrence H, Greene Casey S, Wiita Arun P

Abstract excerpt

A major driver of multiple myeloma (MM) is thought to be aberrant signaling, yet no kinase inhibitors have proven successful in the clinic. Here, we employed an integrated, systems approach combining phosphoproteomic and transcriptome analysis to dissect cellular signaling in MM to inform precision medicine strategies. Unbiased phosphoproteomics initially revealed differential activation of kinases across MM cell...

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Identifiers

PMID: 31698452
DOI: 10.1182/bloodadvances.2019000303
PMCID: PMC6855123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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