Article
Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma.
Blood advances - 12 Nov 2019
Lin Yu-Hsiu T, Way Gregory P, Barwick Benjamin G, Mariano Margarette C, Marcoulis Makeba, Ferguson Ian D, Driessen Christoph, Boise Lawrence H, Greene Casey S, Wiita Arun P
Abstract excerpt
A major driver of multiple myeloma (MM) is thought to be aberrant signaling, yet no kinase inhibitors have proven successful in the clinic. Here, we employed an integrated, systems approach combining phosphoproteomic and transcriptome analysis to dissect cellular signaling in MM to inform precisi...
Topics
- Computational Biology
- Female
- Gene Expression Profiling
- Humans
- MAP Kinase Signaling System
- Machine Learning
- Male
- Molecular Sequence Annotation
- Multiple Myeloma
- Mutation
- Phosphoproteins