Article

Integrated Phosphoproteomics and Transcriptional Classifiers Reveal Hidden RAS Signaling Dynamics in Multiple Myeloma

2019-02-28

Abstract excerpt

<h4>ABSTRACT</h4> A major driver of multiple myeloma is thought to be aberrant signaling, yet no kinase inhibitors have proven successful in the clinic. Here, we employ an integrated, systems approach combining phosphoproteomic and transcriptome analysis to dissect cellular signaling in multiple myeloma to inform precision medicine strategies. Collectively, these predictive models identify vulnerable signaling si...

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Literature Corpus work: 9a8ad891-17ab-54c2-8cf4-fe02a96ca4a4
DOI: 10.1101/563312

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