Back to search

Article

Neuromedin U promotes lung adenocarcinoma progression by enhancing nucleotide metabolism and potentiating fibrosis in the tumor microenvironment

2025-12-05

Abstract excerpt

<title>Abstract</title> <p> Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality, with limited treatment options for EGFR-wild-type patients and persistent intrinsic resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in some EGFR-mutated cases. Neuromedin U (NMU), which encodes a neuropeptide previously associated with poor prognosis, has emerged as a candidate gene linked to reduced EGF...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5d917d9a-8d01-5c94-8246-fe7456f9440f
DOI
10.21203/rs.3.rs-8171505/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Neuromedin U promotes lung adenocarcinoma progression by enhancing nucleotide metabolism and potentiating fibrosis in the tumor microenvironmentDOI 10.21203/rs.3.rs-8171505/v1
Construction of a Prognostic Model for Lung Adenocarcinoma Based on Nucleotide Metabolism-Related Genes and Bioinformatics AnalysisSemantic proximity
Purine metabolism in lung adenocarcinoma: A single‐cell analysis revealing prognostic and immunotherapeutic insightsSemantic proximity
Integrative Multi-Omics and Single-Cell Analyses Reveal that Polyamine Metabolic Reprogramming Shapes an Immunosuppressive Microenvironment and Identifies ZWINT as a Prognostic Biomarker and Therapeutic Target in Lung AdenocarcinomaSemantic proximity
Identification of a novel nucleotide metabolism-related signature for predicting lung adenocarcinoma prognosisSemantic proximity
HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma.Semantic proximity
The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damageSemantic proximity
Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesisSemantic proximity
Nicotinamide N‐methyltransferase negatively regulates metastasis‐promoting property of cancer‐associated fibroblasts in lung adenocarcinomaSemantic proximity
A comprehensive expression profiles and prognostic values analysis of inosine 5'-monophosphate dehydrogenase type II (IMPDH2) in human tumors Running title: A pan-cancer analysis of IMPDH2Semantic proximity
The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It ComplicatedSemantic proximity
Indirect pharmacology of Amorphophallus rivieri Durieu in pancreatic ductal adenocarcinoma: immune-dependent macrophage remodeling and amino acid-related metabolic alterationsSemantic proximity
INSM1 Regulates Neuroendocrine Plasticity and Tumor Progression in Prostate CancerSemantic proximity
Select a neighboring publication to make it the new centre.