Article

Novel Evolution of the Mineralocorticoid Receptor in Humans compared to Chimpanzees, Gorillas and Orangutans

2023-12-09

Abstract excerpt

We identified five distinct full-length human mineralocorticoid receptor (MR) genes containing either 984 amino acids (MR-984) or 988 amino acids (MR-988), which can be distinguished by the presence or absence of Lys, Cys, Ser, Trp (KCSW) in their DNA-binding domain (DBD) and mutations at codons 180 and 241 in their amino terminal domain (NTD). Two human MR-KCSW genes contain either (Val-180, Val-241) or (Ile-180,...

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Literature Corpus work: 5d7349de-032f-5c26-82f6-cbe6687bf104
DOI: 10.1101/2023.12.08.570861

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