Article

Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone

2024-03-14

Abstract excerpt

<title>Abstract</title> <p>Due to alternative splicing in the DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amino acids (MR-984) or 988 amino acids (MR-988), in which their DBDs differ by only four amino acids, Lys,Cys,Ser,Trp (KCSW). Human MRs also contain mutations at two sites, codons 180 and 241, in the amino terminal domain...

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Literature Corpus work: 3cd8251a-83f8-51a2-80d2-2ce330eaebb0
DOI: 10.21203/rs.3.rs-4095590/v1

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