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Rational design of immune gene therapy combinations via <i>in vivo</i> CRISPR activation screen of tumor microenvironment modulators

2023-03-15

Abstract excerpt

The hostile tumor microenvironment (TME) is major challenge for cancer immunotherapies. Here, we design and perform TME-targeted in vivo CRISPR activation (CRISPRa) screens to uncover factors that promote anti-tumor immunity, culminating in rationally designed immune gene therapy combinations. Through adeno-associated virus (AAV) delivery, multiplexed activation of pooled immunoregulatory genes encoding a ntigen...

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Literature Corpus work
d6582228-9f01-5d9f-bc49-239cd0d88e77
DOI
10.1101/2023.03.14.532665
Open publication

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Rational design of immune gene therapy combinations via <i>in vivo</i> CRISPR activation screen of tumor microenvironment modulatorsDOI 10.1101/2023.03.14.532665
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