Publication bias in pharmacogenetics of statin-associated muscle symptoms, an umbrella review with a meta-epidemiological study

Abstract excerpt

<h4>Background</h4> Statin-associated muscle symptoms (SAMS) are a major cause of treatment discontinuation. Adjusting statin dosages for solute carrier organic anion transporter family member 1B1 (SLCO1B1) genotype has been proposed to reduce SAMS. We hypothesized that the association between SLCO1B1 genotype and SAMS is misestimated because of publication bias. <h4>Methods</h4> We searched for published systemat...

Topics

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• Bayes Theorem
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Liver-Specific Organic Anion Transporter 1
• Muscular Diseases
• Pharmacogenetics
• Pharmacogenomic Testing
• Pharmacogenomic Variants
• Publication Bias

Identifiers and source

Literature Corpus work

5d63a0a5-c33d-5674-91d4-f00b717eec43

DOI

10.1101/2024.03.06.24303892