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Article

The autophagy–NAD axis in longevity and disease

5 Mar 2023

Abstract excerpt

Autophagy is an intracellular degradation pathway that recycles subcellular components to maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy metabolism and serves as a substrate for a series of NAD + -consuming enzymes (NADases), including PARPs and SIRTs. Declining levels of autophagic activity and NAD represent features of cellular ageing, and consequently enhancing...

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PMID: 36878731
DOI: 10.1016/j.tcb.2023.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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