Article

ANP32A represses Wnt signaling across tissues tissues thereby protecting against joint and heart disease

2021-04-04

Abstract excerpt

Wnt signaling is key to diverse homeostatic and pathological processes. This cascade is hyper-activated in osteoarthritis, the most common joint disease. Yet, fundamental aspects of Wnt signaling remain undiscovered. Here, we report that ANP32A negatively regulates Wnt signaling across tissues. In cartilage, loss of Anp32a triggered Wnt hyper-activation. Mechanistically, ANP32A directly interacted with Wnt pathwa...

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Literature Corpus work: 5d2f1eac-63cf-5d5a-909d-58bae38b6108
DOI: 10.1101/2021.04.04.438364

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