Article
Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women.
Arthritis and rheumatism - 1 Jul 2009
Valdes Ana M, Lories Rik J, van Meurs Joyce B, Kerkhof Hanneke, Doherty Sally, Hofman Albert, Hart Deborah J, Zhang Feng, Luyten Frank P, Uitterlinden Andre G, Doherty Michael, Spector Tim D
Abstract excerpt
OBJECTIVE: The ANP32A gene encodes a tumor suppressor molecule that plays a regulatory role in apoptosis and interferes with canonical Wnt signaling in vitro. We undertook this study to test whether genetic variation at ANP32A was associated with osteoarthritis (OA) in women. METHODS: Single-nucleotide polymorphisms (SNPs) in the ANP32A gene were genotyped in 438 control women, 425 women with total knee...
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