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Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development

5 Dec 2013

Abstract excerpt

The bone morphogenetic protein (BMP) signaling pathways have important roles in embryonic development and cellular homeostasis, with aberrant BMP signaling resulting in a broad spectrum of human disease. We report that BMPs unexpectedly signal through the canonical transforming growth factor β (TGF‐β)‐responsive Smad2 and Smad3. BMP‐induced Smad2/3 signaling occurs preferentially in embryonic cells and...

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PMID: 24308972
DOI: 10.1096/fj.13-239178

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