Article

PRMT5 as a Novel Druggable Vulnerability for EWSR1-ATF1-driven Clear Cell Sarcoma

2022-03-23

Abstract excerpt

Clear cell sarcoma of soft tissue (CCSST) is an ultra-rare sarcoma with poor prognosis presently with no cure. It is characterized by a balanced t(12;22) (q13;q12) chromosomal translocation, resulting in a fusion of the Ewing’s sarcoma gene EWSR1 with activating transcription factor 1 ( ATF1 ) to give an oncogene EWSR1-ATF1 . Unlike normal ATF1, whose transcription activity is dependent on phosphorylation, EWSR...

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Literature Corpus work: 5cf407e0-42d1-5af2-8172-b5e7cacd1354
DOI: 10.1101/2022.03.23.485409

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