Article

ATF4/NUPR1 axis promotes cancer cell survival and mediates immunosuppression in clear cell renal cell carcinoma

2024-02-20

Abstract excerpt

Cancer cells encounter unavoidable stress during tumor growth. The stress-induced transcription factor, activating transcription factor 4 (ATF4), has been reported to upregulate various adaptive genes involved in salvage pathways to alleviate stress and promote tumor progression. However, this effect is unknown in clear cell renal cell carcinoma (ccRCC). In this study, we found that ATF4 expression was remarkably...

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Literature Corpus work: 55a3003e-2c0f-5174-8035-f61fc8181600
DOI: 10.21203/rs.3.rs-3870049/v1

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