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Article

Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes.

Molecular & cellular proteomics : MCP - 1 Apr 2018

Thriene Kerstin, Grüning Björn Andreas, Bornert Olivier, Erxleben Anika, Leppert Juna, Athanasiou Ioannis, Weber Ekkehard, Kiritsi Dimitra, Nyström Alexander, Reinheckel Thomas, Backofen Rolf, Has Cristina, Bruckner-Tuderman Leena, Dengjel Jörn

Abstract excerpt

The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are linked to skin fragility and progressive inflammation-driven fibrosis that facilitates aggressive skin cancer. So far, these changes have been linked to mesenchymal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29326176
DOI: 10.1074/mcp.RA117.000437
PMCID: PMC5880109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes.PMID 29326176Read ↗

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