Article
Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2016
Khan Muzamil Majid, Lustrino Danilo, Silveira Willian A, Wild Franziska, Straka Tatjana, Issop Yasmin, O'Connor Emily, Cox Dan, Reischl Markus, Marquardt Till, Labeit Dittmar, Labeit Siegfried, Benoit Evelyne, Molgó Jordi, Lochmüller Hanns, Witzemann Veit, Kettelhut Isis C, Navegantes Luiz C C, Pozzan Tullio, Rudolf Rüdiger
Abstract excerpt
The distribution and function of sympathetic innervation in skeletal muscle have largely remained elusive. Here we demonstrate that sympathetic neurons make close contact with neuromuscular junctions and form a network in skeletal muscle that may functionally couple different targets including blood vessels, motor neurons, and muscle fibers. Direct stimulation of sympathetic neurons led to activation of muscle...
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