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Endogenous piRNA-guided slicing triggers responder and trailer piRNA production from viral RNA in <i>Aedes aegypti</i> mosquitoes

2020-07-08

Abstract excerpt

<h4>ABSTRACT</h4> In the germline of animals, PIWI interacting (pi)RNAs protect the genome against the detrimental effects of transposon mobilization. In Drosophila, piRNA-mediated cleavage of transposon RNA triggers the production of responder piRNAs via ping-pong amplification. Responder piRNA 3’ end formation is coupled to the production of downstream trailer piRNAs mediated by the nuclease Zucchini, expandin...

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Literature Corpus work
5cb2ebea-45bb-57d2-9e9b-3c8a027e119b
DOI
10.1101/2020.07.08.193029
Open publication

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