Back to search

Article

A tRNA modification-based regulatory strategy for lincomycin biosynthesis in Streptomyces lincolnensis

2025-11-18

Abstract excerpt

<title>Abstract</title> <p> Lincomycin is a clinically important lincosamide antibiotic. Its biosynthetic efficiency is limited by the presence of the rare UUA codon in the key positive regulators LmbU and AdpA. In this study, we developed a universal metabolic optimization strategy based on tRNA modification engineering. Co-overexpression of the UUA-decoding tRNA gene <italic>bldA</italic> and its post-transc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5cab2f89-ed8e-5604-9bc0-9a3c55163629
DOI
10.21203/rs.3.rs-8038474/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A tRNA modification-based regulatory strategy for lincomycin biosynthesis in Streptomyces lincolnensisDOI 10.21203/rs.3.rs-8038474/v1
The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensisSemantic proximity
Decreased lincomycin B content by regulating osmotic pressure in fermentation of Streptomyces lincolnensisSemantic proximity
Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensisSemantic proximity
A putative redox‐sensing regulator Rex regulates lincomycin biosynthesis in Streptomyces lincolnensisSemantic proximity
An alternative σ factor σLsl regulates lincomycin production in Streptomyces lincolnensisSemantic proximity
Beyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesisSemantic proximity
Mutations within gene XNR_2147 for TetR-like protein enhance lincomycin resistance and endogenous specialized metabolism of Streptomyces albus J1074.Semantic proximity
Identification of a Novel Lincomycin Resistance Mutation Associated with Activation of Antibiotic Production in Streptomyces coelicolor A3(2).Semantic proximity
Interplay between nucleoid-associated proteins and transcription factors in controlling specialized metabolism in <i>Streptomyces</i>Semantic proximity
Interplay between Nucleoid-Associated Proteins and Transcription Factors in Controlling Specialized Metabolism in StreptomycesSemantic proximity
Lincomycin-Induced Secondary Metabolism in Streptomyces lividans 66 with a Mutation in the Gene Encoding the RNA Polymerase Beta Subunit.Semantic proximity
Expression of the regulatory protein LndI for landomycin E production in Streptomyces globisporus 1912 is controlled by the availability of tRNA for the rare UUA codon.Semantic proximity
Select a neighboring publication to make it the new centre.