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An alternative σ factor σLsl regulates lincomycin production in Streptomyces lincolnensis

1 Dec 2022

Abstract excerpt

Abstract Lincomycin produced by Streptomyces lincolnensis is a critical antibacterial antibiotic in the clinical. To further understand the regulatory mechanism of lincomycin biosynthesis, we identified an alternative σ factor, σLsl, in Streptomyces lincolnensis NRRL 2936. Deletion of sigLsl resulted in an increase in cell growth but a decrease in lincomycin production. σLsl boosted lincomycin biosynthesis by...

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PMID: 36453540
DOI: 10.1002/jobm.202200485

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