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Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensis

24 Mar 2018

Abstract excerpt

Streptomyces lincolnensis is generally utilized for the production of lincomycin A (Lin-A), a clinically useful antibiotic to treat Gram-positive bacterial infections. Three methylation steps, catalyzed by three different S-adenosylmethionine (SAM)-dependent methyltransferases, are required in the biosynthesis of Lin-A, and thus highlight the significance of methyl group supply in lincomycin production. In this...

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PMID: 29574602
DOI: 10.1007/s10295-018-2029-1

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