Article

Viral evolution under the pressure of an adaptive immune system: Optimal mutation rates for viral escape

2002-11-01

Abstract excerpt

Abstract Based on a recent model of evolving viruses competing with an adapting immune system (Kamp and Bornholdt, Co‐evolution of quasispecies: B‐cell mutation rates maximize viral error catastrophes. Phys Rev Lett 88, 2002), we study the conditions under which a viral quasispecies can maximize its growth rate. We find that a virus is most viable if it generates on average precisely one mutation within the time i...

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Literature Corpus work: 5c95a446-73ad-5747-b89f-20c6bae4f3dd
DOI: 10.1002/cplx.10067

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