Article
Host-parasite coevolution and optimal mutation rates for semiconservative quasispecies.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Jun 2004
Brumer Yisroel, Shakhnovich Eugene I
Abstract excerpt
In this paper, we extend a model of host-parasite coevolution to incorporate the semiconservative nature of DNA replication for both the host and the parasite. We find that the optimal mutation rate for the semiconservative and conservative hosts converge for realistic genome lengths, thus maintaining the admirable agreement between theory and experiment found previously for the conservative model and justifying...
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