Article

A multi-layered approach to elucidate mechanisms of physical function in response to rehabilitation in heart failure with preserved ejection fraction

2026-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Heart failure with preserved ejection fraction (HFpEF) is an increasingly common cause of morbidity and mortality in older adults that is driven by cardiac and non-cardiac mechanisms. Physical rehabilitation improves frailty and functional capacity in HFpEF, though underlying mechanisms remain less clear. We quantified >5,000 circulating proteins across two randomized clinical trials of rehabili...

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Literature Corpus work: 5c83a5ff-b429-5e67-9de5-481a6ca717b3
DOI: 10.64898/2026.02.12.26346203

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