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Article

Proteomic architecture of frailty across the spectrum of cardiovascular disease

20 Sept 2023

Abstract excerpt

While frailty is a prominent risk factor in an aging population, the underlying biology of frailty is incompletely described. Here, we integrate 979 circulating proteins across a wide range of physiologies with 12 measures of frailty in a prospective discovery cohort of 809 individuals with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation. Our aim was to characterize the proteomic...

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PMID: 37731195
DOI: 10.1111/acel.13978

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