Back to search

Article

Substantial Downregulation of Mitochondrial and Peroxisomal Proteins during Acute Kidney Injury revealed by Data-Independent Acquisition Proteomics

2023-02-26

Abstract excerpt

Acute kidney injury (AKI) manifests as a major health concern, particularly for the elderly. Understanding AKI-related proteome changes is critical for prevention and development of novel therapeutics to recover kidney function and to mitigate the susceptibility for recurrent AKI or development of chronic kidney disease. In this study, mouse kidneys were subjected to ischemia-reperfusion injury, and the contralate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5c6e8aad-ba67-5c1b-bdeb-5784c2b2a524
DOI
10.1101/2023.02.26.530107
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Substantial Downregulation of Mitochondrial and Peroxisomal Proteins during Acute Kidney Injury revealed by Data-Independent Acquisition ProteomicsDOI 10.1101/2023.02.26.530107
Genomic and Proteomic Characterization of Acute Kidney InjurySemantic proximity
Multi-omics characterization of human kidneys identifies cPLA2-arachidonic acid metabolism as a potential driver of inflammationSemantic proximity
Mitochondrial Bioenergetic and Proteomic Phenotyping Reveals Organ-Specific Consequences of Chronic Kidney Disease in Mice.Semantic proximity
Plasma proteomics of acute tubular injurySemantic proximity
Early Lipid Remodeling During Ischemia–Reperfusion Injury Is Associated with Damage- and Protection-Related Lipid Signatures in Acute Kidney InjurySemantic proximity
Hypoxic injury triggers maladaptive repair in human kidney organoidsSemantic proximity
iTRAQ-based comparative proteomics analysis reveals specific urinary biomarkers for various kidney diseasesSemantic proximity
Adenine-induced kidney disease alters the cortical bone metabolome of C57BL/6J mice in a manner that depends on sexSemantic proximity
Definitions of acute renal dysfunction: an evolving clinical and biomarker paradigm.Semantic proximity
Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy.Semantic proximity
Vitamin B12 Protects the Exacerbated Ischemia-Reperfusion Injury Induced Chronic-Kidney-Disease in Mice with Genetically Increased Elmo1Semantic proximity
Direct Imaging and Identification of Proteoforms up to 70 kDa from Human TissueSemantic proximity
Select a neighboring publication to make it the new centre.