Article

Evidence of Altered Monoamine Oxidase B, an Astroglia Marker, in Early Psychosis with Cannabis Use

2024-03-15

Abstract excerpt

<title>Abstract</title> <p>A novel radiotracer, [<sup>11</sup>C]SL25.1188 targets monoamine oxidase-B (MAO-B) enzyme, which metabolizes monoamines (including dopamine) primarily found in astrocytes. Altered astrocyte function in schizophrenia is supported by convergent evidence from post-mortem, genetic, transcriptomic, peripheral and preclinical findings. However, this has never been tested in living brains of e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c57edd1-15af-5981-b13f-b71ffe788f87
DOI: 10.21203/rs.3.rs-4058038/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evidence of Altered Monoamine Oxidase B, an Astroglia Marker, in Early Psychosis with Cannabis UseDOI 10.21203/rs.3.rs-4058038/v1Read

Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis.Semantic proximity Read

Basal ganglia subregion volume changes between acute-phase schizophrenia and bipolar disorderSemantic proximity Read

Monoamine Oxidases (MAOs) as Privileged Molecular Targets in Neuroscience: Research Literature AnalysisSemantic proximity Read

Assessing the relationships between neurological and psychiatric diseases with astrocyte subtypes and psychotropic medicationsSemantic proximity Read

Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disordersSemantic proximity Read

[Psychosis and bipolar disorders--neuro-imaging and genetics].Semantic proximity Read

5-HT2A receptor density is decreased in the at-risk mental state.Semantic proximity Read

Neuroanatomical substrates in Parkinson’s Disease psychosis and their association with serotonergic receptor gene expression: A coordinate-based meta-regression analysisSemantic proximity Read

Terminal type-specific cannabinoid CB1 receptor alterations in patients with schizophrenia: a pilot studySemantic proximity Read

Poorer frontolimbic white matter integrity is associated with chronic cannabis use, FAAH genotype, and increased depressive and apathy symptoms in adolescents and young adults.Semantic proximity Read

Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorderSemantic proximity Read

Schizophrenia-Like Features in Transgenic Mice Overexpressing Human HO-1 in the Astrocytic CompartmentSemantic proximity Read