Poorer frontolimbic white matter integrity is associated with chronic cannabis use, FAAH genotype, and increased depressive and apathy symptoms in adolescents and young adults.

doi:10.1016/j.nicl.2015.03.024

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Poorer frontolimbic white matter integrity is associated with chronic cannabis use, FAAH genotype, and increased depressive and apathy symptoms in adolescents and young adults.

NeuroImage. Clinical - 1 Jan 2015

Shollenbarger Skyler G, Price Jenessa, Wieser Jon, Lisdahl Krista

Abstract excerpt

BACKGROUND: The heaviest period of cannabis use coincides with ongoing white matter (WM) maturation. Further, cannabis-related changes may be moderated by FAAH genotype (rs324420). We examined the association between cannabis use and FAAH genotype on frontolimbic WM integrity in adolescents and emerging adults. We then tested whether observed WM abnormalities were linked with depressive or apathy symptoms....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cannabis

Share to Depression

Share to Frontal Lobe

Share to Limbic System

Share to Magnetic Resonance Imaging

Share to White Matter

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 26106535
DOI: 10.1016/j.nicl.2015.03.024
PMCID: PMC4473294

Genes

FAAH
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poorer frontolimbic white matter integrity is associated with chronic cannabis use, FAAH genotype, and increased depressive and apathy symptoms in adolescents and young adults.PMID 26106535Read ↗

Generalized and specific whole-brain white matter abnormalities in human cocaine and heroin use disordersSemantic proximity Read ↗

Effect of high-potency cannabis on corpus callosum microstructureSemantic proximity Read ↗

Structural connectome architecture and biological vulnerability shape cortical atrophy in cocaine use disorderSemantic proximity Read ↗

Association of polygenic risk for cannabis use disorder with brain structure among youth with and without bipolar disorder.Semantic proximity Read ↗

Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism.Semantic proximity Read ↗

Depression, marijuana use and early-onset marijuana use conferred unique effects on neural connectivity and cognition.Semantic proximity Read ↗

Network and receptor architectures shape brain morphometry in addictionSemantic proximity Read ↗

Structural connectome architecture and biological vulnerability shape cortical atrophy in cocaine use disorderSemantic proximity Read ↗

Investigating the white matter tract pattern in ADHD compared to healthy controlsSemantic proximity Read ↗

Unveiling causal relationship between white matter tracts and psychiatric disordersSemantic proximity Read ↗

Lifetime use of cannabis from longitudinal assessments, cannabinoid receptor (CNR1) variation, and reduced volume of the right anterior cingulate.Semantic proximity Read ↗

Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.