Article

Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens

2026-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Herpes simplex virus type 2 (HSV-2) causes genital herpes through latent infection and periodic reactivation. Although antivirals alleviate symptoms, no prophylactic or therapeutic vaccines have been licensed. Glycoprotein B (gB) is a class III fusion protein that mediates entry by irreversibly transitioning from a metastable prefusion conformation to a stable postfusion conformation. Leveraging...

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Literature Corpus work: 5c501dca-b78a-5e54-819d-258c5e5234f1
DOI: 10.64898/2026.01.26.701809

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