Article

Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen

2025-05-19

Abstract excerpt

Epstein-Barr virus (EBV), the causative agent of mononucleosis, is linked to over 140,000 annual cancer-related deaths globally and increases the risk of multiple sclerosis by up to 32-fold. As a herpesvirus, EBV establishes lifelong infection, and over 90% of U.S. adults are EBV-seropositive. Despite its significant disease burden, no approved EBV vaccines or therapeutics exist. Among EBV envelope glycoproteins,...

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Literature Corpus work: 7b33483b-ce65-5746-bc3b-5fe026e8868c
DOI: 10.1101/2025.05.19.654955

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