Back to search

Article

DNA methylation changes associated with acquired platinum resistance in ovarian cancer

2011-01-01

Abstract excerpt

Despite high responses to initial chemotherapy most patients with ovarian cancer (OC) relapse and inevitably die from their disease. Aberrant DNA methylation is frequently seen in ovarian tumours and may provide biomarkers of clinical outcome or insight into mechanisms of chemoresistance. We firstly performed Differential Methylation Hybridisation (DMH) to identify loci that gained methylation between 34 matched c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
229ccabd-fb87-5404-937d-2342d3ce45a3
DOI
10.25560/9000
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DNA methylation changes associated with acquired platinum resistance in ovarian cancerDOI 10.25560/9000
Biostatistical analysis of DNA methylation profiling in ovarian cancerSemantic proximity
Unveiling the epigenomic mechanisms of acquired platinum‐resistance in high‐grade serous ovarian cancerSemantic proximity
The epigenetic response to platinum-induced DNA damage and repairSemantic proximity
The discovery and evaluation of treatment stratification biomarkers in epithelial ovarian cancerSemantic proximity
Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian CancerSemantic proximity
Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancerSemantic proximity
Chemosensitivity associated chromatin conformation changes and genomic cisplatin-DNA adduct distributionSemantic proximity
Comprehensive Analysis of DNA Methyltransferases Expression in Primary and Relapsed Ovarian CarcinomaSemantic proximity
Promoter Methylation of the MGRN1 Gene Response to Chemotherapy of Epithelial Ovarian Cancer PatientsSemantic proximity
Decitabine reactivated pathways in platinum resistant ovarian cancerSemantic proximity
Resistance to cis- and carboplatin initiated by epigenetic changes in ovarian cancer patientsSemantic proximity
Hypermethylation of mismatch repair gene hMSH2 associates with platinum-resistant disease in epithelial ovarian cancerSemantic proximity
Select a neighboring publication to make it the new centre.