Article

Spatial dynamics of the tumor microenvironment linked to emerging resistance in <i>EGFR</i> -mutated lung cancer

2025-02-13

Abstract excerpt

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide therapeutic benefit in EGFR mutation–positive non–small cell lung cancer, but some individuals develop early resistance. We performed spatial transcriptomics analysis of pre- and posttreatment tumor samples from the same patients to explore the underlying mechanisms of such early resistance. The proportion and activation of fibrobla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c099b0f-d3c1-528b-984e-3169a828140f
DOI: 10.1101/2025.02.10.637543

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial dynamics of the tumor microenvironment linked to emerging resistance in <i>EGFR</i> -mutated lung cancerDOI 10.1101/2025.02.10.637543Read

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLCSemantic proximity Read

Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma ProgressionSemantic proximity Read

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.Semantic proximity Read

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancerSemantic proximity Read

Spatially resolved transcriptomics reveal the determinants of primary resistance to immunotherapy in NSCLC with mature tertiary lymphoid structuresSemantic proximity Read

Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypesSemantic proximity Read

Single-Cell Analysis Reveals Spatial Heterogeneity of Immune Cells in Lung AdenocarcinomaSemantic proximity Read

Characterizing the Dynamics of the Single Cell Tumor Microenvironment and Immune Cell Subpopulations during the Progression of Lung AdenocarcinomaSemantic proximity Read

Distinct Spatial Programs of Response versus Resistance in Non-Small Cell Lung Cancer after Neoadjuvant ChemoimmunotherapySemantic proximity Read

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma.Semantic proximity Read

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung CancerSemantic proximity Read

Biomarker exploration for immunotherapy plus chemotherapy following resistance to third-generation EGFR-TKIs in lung adenocarcinoma.Semantic proximity Read