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[Mutant calreticulin and the molecular mechanisms in development of myeloproliferative neoplasms].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2020

Araki Marito

Abstract excerpt

This review aimed to evaluate the molecular mechanism underlying the development of myeloproliferative neoplasms (MPN) caused by mutant calreticulin (CALR). This mutation is found in a subset of patients with Philadelphia chromosome-negative MPNs, and it encodes a molecular chaperone. However, it is essentially impossible to elucidate the oncogenic property of mutant CALR from the wild-type CALR function. Studies...

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PMID: 32908058
DOI: 10.11406/rinketsu.61.937

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