Article

Lysosomal Degradation Pathways Target Mutant Calreticulin and the Thrombopoietin Receptor in Myeloproliferative Neoplasms

2023-07-12

Abstract excerpt

Somatic mutants of calreticulin (CRT) drive myeloproliferative neoplasms (MPNs) via binding to the thrombopoietin receptor (MPL) and aberrant activation of the JAK/STAT pathway. Compared with healthy donors, platelets from MPN patients with CRT mutations display low cell surface MPL. Co-expression of MPL with an MPN-linked CRT mutant (CRT Del52 ) reduces cell surface MPL expression, indicating the involvement of...

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Literature Corpus work: 92d2afb3-88b4-51af-afd0-6f1c0c4210c0
DOI: 10.1101/2023.07.12.548605

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