Article

Vitamin B12 alleviates spliceosomopathy via phospholipid remodeling

2025-11-17

Abstract excerpt

<title>Abstract</title> <p> Spliceosomal dysfunction profoundly impacts cellular metabolism, yet mechanistic links between RNA splicing defects and metabolic rewiring remain limited. Here, we investigate Verheij syndrome (VRJS), a rare disease caused by mutations in the core splicing factor <italic>PUF60</italic> . Using a <italic>Caenorhabditis elegans</italic> model, human cell lines, and patient-derived s...

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Literature Corpus work: 5bf33908-fd42-57de-ac73-e88daeb2fea6
DOI: 10.21203/rs.3.rs-8077579/v1

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